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Visceral Leishmaniasis Drug Enters Phase II Trial in Ethiopia

World Health Organization | Communicable Disease

Visceral Leishmaniasis Drug Enters Phase II Trial in Ethiopia

“Also known as kala-azar, visceral leishmaniasis is the world’s deadliest parasitic killer after malaria.

It causes fever, weight loss, spleen and liver enlargement, and, if not treated, death. Kala-azar is transmitted by the bite of infected sandflies and is endemic in 80 countries, mainly in Eastern Africa, South Asia, and Latin America. One billion people are at risk globally and Eastern Africa has currently the highest number of cases. As for other vector-borne diseases, climate change is changing the epidemiology of leishmaniasis and could lead to its expansion to new areas. An estimated 50,000 to 90,000 new cases occur worldwide annually, and half are children under 15 years of age.

In Africa, the current treatment for visceral leishmaniasis includes painful injections given at hospital daily for 17 days, a treatment that may also present rare but life-threatening side effects, including to the heart, liver, and pancreas. In contrast, the new molecule under study in Ethiopia, called LXE408, is administered in the form of oral pills and is expected to be safer than the current treatment.”

From World Health Organization.

Blog Post | Accidents, Injuries & Poisonings

Driving in 2021 Was 225 Percent Safer than in 1970

Deaths per traffic mile have decreased by 69.3 percent while miles per gallon increased by 95.4 percent.

Summary: Over the span of five decades, advancements in vehicle safety technology have contributed to substantial improvements in traffic safety. Meanwhile, significant enhancements in fuel efficiency have been achieved. If you define travel abundance as a combination of these two factors, then abundance has increased by 596 percent.


Between 1970 and 2021, the rate of traffic deaths for every 100 million miles driven decreased by 69.3 percent, from 4.88 to 1.50, according to the National Safety Council.

Vehicle miles driven increased 179.8 percent from 1.12 billion miles in 1970 to 3.13 billion in 2021. During this same period, the number of deaths decreased by 14 percent from 54,633 to 46,980.

If traffic safety hadn’t improved since 1970, there would have been 152,842 traffic deaths in 2021 instead of 46,980. That means 105,862 more people are alive thanks to better traffic safety measures. Adjusted for miles driven, for every traffic death in 2021, there were 3.25 in 1970 (4.88 ÷ 1.5 = 3.25).

The opposite of the death rate would be the life safety rate. If we index traffic safety at a value of 1 in 1970, the rate would be 3.25 in 2021. Measured from this perspective, 2021 was 225 percent safer than 1970. Vehicle safety has been increasing at a compound annual rate of 2.34 percent, doubling every 30 years.

Cars and drivers are both getting safer by getting smarter. Cars today have three-point seat belts, air bags, stability control, backup cameras, blind spot detection, anti-lock brakes, radial belted tires, headrests, tire pressure monitoring, automatic emergency braking, lane departure warning, adaptive headlights, adaptive cruise control, and anchors for child seats.

We also get much better mileage. The full-size Ford Galaxie took the number-one spot in sales for 1970. It got 13 to 16 miles per gallon. Today’s bestseller is the Honda CRV, which gets 28 to 34 miles per gallon. Gas mileage has increased by 114 percent while safety has improved by 225 percent. If you define travel abundance as a combination of these two factors, then abundance has increased by 596 percent.

This article was published at Gale Winds on 4/24/2024.

Associated Press | Health & Medical Care

Will AI Replace Doctors Who Read X-Rays?

“The first large, rigorous studies testing AI-assisted radiologists against those working alone give hints at the potential improvements.

Initial results from a Swedish study of 80,000 women showed a single radiologist working with AI detected 20% more cancers than two radiologists working without the technology.

In Europe, mammograms are reviewed by two radiologists to improve accuracy. But Sweden, like other countries, faces a workforce shortage, with only a few dozen breast radiologists in a country of 10 million people.

Using AI instead of a second reviewer decreased the human workload by 44%, according to the study.”

From Associated Press.

U.S. News | Drug Use

US Drug Overdose Deaths Decline for First Time in 5 Years

“The relentless rise in deaths from drug overdose in the United States may finally have stalled: New data from 2023 show the first decline in such deaths since 2018.

‘Statistics indicate there were an estimated 107,543 drug overdose deaths in the United States during 2023 — a decrease of 3% from the 111,029 deaths estimated in 2022,’ CDC statisticians wrote.”

From U.S. News.