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01 / 05
Why Measles Making the News Is a Sign of Progress

Blog Post | Communicable Disease

Why Measles Making the News Is a Sign of Progress

Not long ago, measles was so common that it was simply not newsworthy.

A set of measles outbreaks in Washington state, New York City, and elsewhere, is making national headlines and frightening parents around the United States. Counter-intuitively, measles making the news is a sign of progress. Not long ago, measles was so common that it was simply not newsworthy. Suffering from the extremely infectious disease, which causes spotty rashes and a hacking cough, was widespread and often deadly.

It was once the case that even royalty fell victim to diseases now easily preventable with routine shots given during childhood. Measles killed the un-vaccinated King Kamehameha II of Hawaii, and his queen, Kamamalu, in the 1800s. A century prior to that, King Louis XIV of France lost his brother, son, grandson, and great-grandson to smallpox. Smallpox once claimed approximately 400,000 lives annually in Europe in the late 18th century, and in the 20th century, it caused hundreds of millions of deaths around the world. Thanks to vaccines, smallpox was eradicated in 1980.

As recently as the late 1950s and early 1960s, nearly twice as many children died from measles as from the polio disease. Thanks, once again, to vaccines, polio was eliminated from the United States in 1979.

Recent coverage by the Washington Post of the current measles outbreaks contains an amazing anecdote of a measles victim’s visit to a doctor: “the doctor, who had never seen measles, misdiagnosed the man’s fever and cough as bronchitis.” That measles is now so rare that even a trained medical doctor cannot recognize it, when just a generation ago it was a common childhood ailment, is truly a triumph of medical progress.

As recently as 1990, measles caused over 22 deaths per 100,000 people globally. Thanks to the measles vaccine and rising global vaccination rates, that figure fell to just over 1 per 100,000 people by 2016, the most recent year for which there is data. That represents a decline in measles deaths of over 95 percent.

The current uptick in measles cases is troubling. But the fact that measles cases are making the news at all is a testament to medical progress.

Medical Xpress | Vaccination

New Vaccine Triggers Immune Response to Fight Brain Tumor

“In a first-ever human clinical trial of four adult patients, an mRNA cancer vaccine developed at the University of Florida quickly reprogrammed the immune system to attack glioblastoma, the most aggressive and lethal brain tumor…

Reported May 1 in the journal Cell, the discovery represents a potential new way to recruit the immune system to fight notoriously treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.”

From Medical Xpress.

World Health Organization | Vaccination

Major Step in Malaria Prevention in Three West African Countries

“In a significant step forward for malaria prevention in Africa, three countries—Benin, Liberia and Sierra Leone—today launched a large-scale rollout of the life-saving malaria vaccine targeting millions of children across the three West African nations. The vaccine rollout, announced on World Malaria Day, seeks to further scale up vaccine deployment in the African region.

Today’s launch brings to eight the number of countries on the continent to offer the malaria vaccine as part of the childhood immunization programmes, extending access to more comprehensive malaria prevention. Several of the more than 30 countries in the African region that have expressed interest in the vaccine are scheduled to roll it out in the next year through support from Gavi, the Vaccine Alliance, as efforts continue to widen its deployment in the region in coordination with other prevention measures such as long-lasting insecticidal nets and seasonal malaria chemoprevention.”

From World Health Organization.

World Health Organization | Vaccination

Immunization Efforts Saved 154 Million Lives over past 50 Years

“A major landmark study to be published by The Lancet reveals that global immunization efforts have saved an estimated 154 million lives – or the equivalent of 6 lives every minute of every year – over the past 50 years. The vast majority of lives saved – 101 million – were those of infants.

The study, led by the World Health Organization, shows that immunization is the single greatest contribution of any health intervention to ensuring babies not only see their first birthdays but continue leading healthy lives into adulthood.

Of the vaccines included in the study, the measles vaccination had the most significant impact on reducing infant mortality, accounting for 60% of the lives saved due to immunization. This vaccine will likely remain the top contributor to preventing deaths in the future.”

From World Health Organization.

The Guardian | Vaccination

“Real Hope” for Cancer Cure as Personal mRNA Vaccine Trialled

“Experts are testing new jabs that are custom-built for each patient and tell their body to hunt down cancer cells to prevent the disease ever coming back.

A phase 2 trial found the vaccines dramatically reduced the risk of the cancer returning in melanoma patients. Now a final, phase 3, trial has been launched and is being led by University College London Hospitals NHS Foundation Trust (UCLH).”

From The Guardian.