“Last year, researchers published the trial’s primary results, which showed that semaglutide reduced participants’ risk of heart attack, stroke, and cardiovascular-related deaths by 20 percent over the span of a little over three years.

In the new analysis with yet longer follow-up of the same participants, researchers focused on their weight-loss trajectories and endpoints. People taking semaglutide saw their weight decline steadily over the first 65 weeks of treatment, then plateauing. However, the initial weight loss was sustained through 208 weeks (four years) of follow-up. On average, people taking the drug lost 10.2 percent of their weight, while the placebo group lost just 1.5 percent. That amounts to an 8.7 percent treatment difference.”

From Ars Technica.