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01 / 05
Targeted Cancer Drugs Finally Live Up to the Hype

Bloomberg | Noncommunicable Disease

Targeted Cancer Drugs Finally Live Up to the Hype

“Cancer drugs that work like heat-seeking missiles to deliver chemicals directly to tumors are having a bit of a moment. Pharmaceutical companies, in need of assets to counter flagging sales, are making these so-called antibody-drug conjugates the technology of choice in oncology dealmaking, as illustrated by last week’s $10.1 billion acquisition of ImmunoGen Inc. by AbbVie Inc. … After decades of fits and starts, the science around designing and testing this class of drugs has finally coalesced. The concept of deploying powerful chemo drugs to cancer cells in a targeted, safer way always made sense; now, companies know how to do it in a manner that could make them a staple of cancer care.”

From Bloomberg.

CNN | Noncommunicable Disease

ALS Patient’s Brain Implant Translates Thoughts to Computer Commands

“Staring at a computer screen, Mark focuses deeply, his arms resting by his side. His right index finger trembles ever so slightly on top of a pillow, and then an alert rings out from the screen in front of him, a message to a caregiver that he needs assistance.

Without ever clicking a mouse or touching a screen, Mark selected this command on his computer simply using signals from his brain. Mark, whom CNN agreed to identify using only his first name for privacy reasons, has an implant inside his brain that is translating his neural activity to commands on a computer.

Mark is only the 10th person in the world implanted with this particular type of brain-computer interface, or BCI. He’s participating in a human trial with a company called Synchron and underwent the procedure in August, after being diagnosed with amyotrophic lateral sclerosis – sometimes called ALS or Lou Gehrig’s disease – in 2021.

The hope is that the technology in Mark’s brain could assist him and others like him who are losing their motor function.”

From CNN.

CNN | Noncommunicable Disease

Spinal Cord Implant Helps Parkinson’s Patient Walk in New Study

“Marc Gauthier can now step into an elevator without his body stiffening and freezing in place. He can take a 3-mile lakeside stroll without stopping. He can stand up out of a chair with ease. For Gauthier, 63, who has been living with Parkinson’s disease for almost three decades, these everyday activities were a challenge — until now.

‘Walking in a store would be really difficult, impossible before, because of the freezing of gait that would often happen in those environments. And now, it just doesn’t happen anymore. I don’t have freezing anymore,’ Gauthier, who lives near Bordeaux, France, said in a news briefing, speaking in French that was translated to English.

In a new study, Gauthier was surgically implanted with an experimental spinal cord neuroprosthesis to correct walking disorders in people with Parkinson’s disease. Step by step, he said, it has helped him get his stride back.”

From CNN.

New York Times | Noncommunicable Disease

Patient Begins Newly Approved Sickle Cell Gene Therapy

“On Wednesday, Kendric Cromer, a 12-year-old boy from a suburb of Washington, became the first person in the world with sickle cell disease to begin a commercially approved gene therapy that may cure the condition.

For the estimated 20,000 people with sickle cell in the United States who qualify for the treatment, the start of Kendric’s monthslong medical journey may offer hope. But it also signals the difficulties patients face as they seek a pair of new sickle cell treatments.

For a lucky few, like Kendric, the treatment could make possible lives they have longed for.”

From New York Times.

STAT | Noncommunicable Disease

New Mosquito Nets Prevented 13 Million Malaria Cases in Pilot Programs

“Results shared this week by the New Nets Project, an initiative funded by Unitaid and the Global Fund, highlighted a pair of second-generation bed nets tested in endemic areas between 2019 and 2022. About 56 million nets were distributed in Burkina Faso, Benin, and Côte d’Ivoire, among other countries, and several pilot studies found that the new nets were between 20% and 50% more effective than traditional ones in reducing mosquito exposure and reduced the risk of infection by up to 55%. Overall, the New Net Project estimated the nets helped prevent up to 13 million additional cases of malaria, saving close to 25,000 lives.”

From STAT.