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01 / 05
Heroes of Progress, Pt. 6: Alexander Fleming

Blog Post | Sickness & Disease

Heroes of Progress, Pt. 6: Alexander Fleming

Introducing the man who discovered penicillin, Alexander Fleming.

Today is the sixth installment of a new series of articles by HumanProgress.org titled, The Heroes of Progress. This bi-weekly column provides a short introduction to unsung heroes who have made an extraordinary contribution to the wellbeing of humanity. You can find the 5th part of this series here.

Our sixth Hero of Progress is Alexander Fleming, the man who first discovered penicillin. Fleming’s discovery paved the way for the invention of antibiotic drugs, which have been credited with saving over 80 million lives so far.

Alexander Fleming was born on August 6, 1881, in Ayrshire, Scotland. At the age of 13, Fleming moved to London to attend the Royal Polytechnic Institution. After inheriting some money from a dying uncle at the age of 21, he enrolled at St. Mary’s Hospital Medical School, London. Fleming graduated with distinction in 1906 and stayed at the medical school as a researcher of bacteriology under Sir Almroth Wright – a pioneer in vaccine therapy and immunology.

When World War One began, Fleming enrolled in the Army Medical Corps. He returned to St. Mary’s to work as a lecturer in 1918. However, it would be another 10 years before his world-changing discovery.

On 3rd September 1928, Fleming returned to his lab having spent August on a holiday with his family. Fleming was notorious for his messy lab. Upon returning from a long vacation in 1928, he discovered that he had left out petri dishes of staphylococci, a common bacterium found in 25 percent of healthy people. Upon investigation, he noticed that the bacteria were infected and destroyed by a fungus, which he identified as being from the genus Penicillium. Further investigations revealed that penicillin destroys bacteria by attacking its cell wall and interfering with its ability to reproduce.

Penicillin was able to fight all gram-positive bacteria (a type of bacteria with a more penetrable cell wall), which includes those that cause diphtheria, meningitis, scarlet fever and pneumonia.

Fleming published his discovery in 1929 in the British Journal of Experimental Pathology. However, little attention was paid to his findings at the time. He continued with his experiments but found that cultivation of penicillin was difficult. After having grown the mold, isolating the antibiotic agent proved strenuous. Lacking the funds and manpower needed for more in-depth research, Fleming abandoned his pursuit after a series of inconclusive experiments.

During World War Two, Howard Florey and Ernst Boris Chain from Oxford University managed to get a carefully preserved strain of Fleming’s penicillin. Florey and Chain began large-scale research, hoping to be able to mass-produce the antibiotic.

Mass production began after the bombing of Pearl Harbor, and by D-Day in 1944, enough penicillin had been produced to treat all wounded allied troops.

In 1944, Fleming was knighted by King George VI and became “Sir Alexander Fleming.” The next year Fleming, Florey and Chain jointly won the Nobel Prize for their contribution to developing the antibiotic.

Looking back on the day of his discovery, Fleming once said, “One sometimes finds what one is not looking for. When I woke up… I certainly didn’t plan to revolutionize all medicine by discovering the world’s first antibiotic or bacteria killer. But I suppose that’s exactly what I did.”

Later in life Fleming was decorated with numerous awards: he was an honorary member of almost all medical and scientific societies across the world, he became a “Freeman” of many boroughs and cities, and was awarded honorary doctorate degrees from almost thirty universities across Europe and America. He died aged 73, in 1955.

Fleming’s discovery of penicillin laid the foundation for the development of the antibiotic “wonder drug” that has been credited with saving over 80 million lives. Penicillin revolutionized the medical field and it is likely that most people reading this today have benefited from Fleming’s discovery at some point in their lives. It is for this reason Alexander Fleming deserves to be our sixth Hero of Progress.

World Health Organization | Communicable Disease

Progress Toward Malaria Elimination

“In the late 1990s, world leaders laid the foundation for remarkable progress in global malaria control, including preventing more than 2 billion cases of malaria and nearly 13 million deaths since 2000.

To date, WHO has certified 45 countries and 1 territory as malaria-free, and many countries with a low burden of malaria continue to move steadily towards the goal of elimination. Of the remaining 83 malaria-endemic countries, 25 reported fewer than 10 cases of the disease in 2023…

Years of investment in the development and deployment of new malaria vaccines and next-generation tools to prevent and control malaria are paying off.

On World Malaria Day, Mali will join 19 other African countries in introducing malaria vaccines—a vital step towards protecting young children from one of the continent’s most deadly diseases. The large-scale rollout of malaria vaccines in Africa is expected to save tens of thousands of young lives every year.

Meanwhile, the expanded use of a new generation of insecticide-treated nets is poised to lower the disease burden. According to the latest World malaria report, these new nets—which have greater impact against malaria than the standard pyrethroid-only nets—accounted for nearly 80% of all nets delivered in sub-Saharan Africa in 2023, up from 59% the previous year.”

From World Health Organization.

Gavi | Vaccination

Malaria Vaccination Sees Child Deaths Drop in Kenya’s Lake Region

“Gumbo, the [Lake Region Economic Block] health pillar lead, reports that the vaccine, alongside other existing malaria interventions, has helped all-cause mortality among children to drop in this region.

He says that while the counties are yet to release official data on the same, statistics from hospitals within have shown a great reduction of prevalence of severe malaria.

‘We might be having hospitalisation of vaccinated children with malaria, but the severity has reduced, their chances of survival are also higher,’ he said.”

From Gavi.

Quillette | Communicable Disease

Poisoning Mosquitoes with Human Blood

“A groundbreaking recent study shows that mosquitoes can be poisoned by the blood of people taking a specific medication. The drug, nitisinone, is already approved by the US Food and Drug Administration for treating certain rare genetic disorders, and researchers have now found that it is also highly effective at killing malaria-carrying mosquitoes.

The concept of poisoning mosquitoes through their blood meals isn’t entirely new. In the past, scientists have investigated ivermectin, a widely used antiparasitic drug, as a potential mosquito-killing agent. The idea is simple: When a mosquito bites a person or animal treated with ivermectin, the drug enters the mosquito’s system and ultimately kills it. However, ivermectin has limitations—it works relatively slowly, taking up to four days to kill mosquitoes, and its effects wear off quickly in the bloodstream.

Nitisinone presents a more promising alternative. Unlike traditional insecticides, which typically target the mosquito’s nervous system, nitisinone disrupts a crucial enzyme (HPPD) that mosquitoes need to digest their blood meal. Without this enzyme, mosquitoes experience a metabolic shutdown, leading to death within 24 hours—far faster than with ivermectin.

Perhaps most excitingly, nitisinone appears to be effective at much lower doses than previously expected. Even blood from people taking small amounts of the drug proved lethal to mosquitoes. This means that individuals in malaria-endemic regions could potentially take a safe low dose of nitisinone, turning their blood into a mosquito-killing agent without significant side effects.”

From Quillette.

Pan American Health Organization | Communicable Disease

South America Nears Eradication of Foot-and-Mouth Disease

“Two out of three cattle in South America are currently located in foot-and-mouth disease (FMD)-free zones where vaccination is not practiced. Across the entire Americas, more than 80% of cattle are in this condition, bringing the region closer to the eradication of the disease…

FMD free zone or country where vaccination is not practiced means that countries have managed to eradicate the disease without relying on systematic vaccination of cattle, which reduces associated costs and improves competitiveness in international markets.

FMD has represented a long-standing threat to food security and the economies of countries in the Americas. Vaccinating cattle has been the primary strategy to control outbreaks and prevent new cases, enabling several countries to achieve eradication. Once the absence of virus transmission is confirmed and internal risks in a territory are eliminated, countries can suspend vaccination and maintain eradication without the need for ongoing vaccination.”

From Pan American Health Organization.