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01 / 05
Heroes of Progress, Pt. 6: Alexander Fleming

Blog Post | Sickness & Disease

Heroes of Progress, Pt. 6: Alexander Fleming

Introducing the man who discovered penicillin, Alexander Fleming.

Today is the sixth installment of a new series of articles by HumanProgress.org titled, The Heroes of Progress. This bi-weekly column provides a short introduction to unsung heroes who have made an extraordinary contribution to the wellbeing of humanity. You can find the 5th part of this series here.

Our sixth Hero of Progress is Alexander Fleming, the man who first discovered penicillin. Fleming’s discovery paved the way for the invention of antibiotic drugs, which have been credited with saving over 80 million lives so far.

Alexander Fleming was born on August 6, 1881, in Ayrshire, Scotland. At the age of 13, Fleming moved to London to attend the Royal Polytechnic Institution. After inheriting some money from a dying uncle at the age of 21, he enrolled at St. Mary’s Hospital Medical School, London. Fleming graduated with distinction in 1906 and stayed at the medical school as a researcher of bacteriology under Sir Almroth Wright – a pioneer in vaccine therapy and immunology.

When World War One began, Fleming enrolled in the Army Medical Corps. He returned to St. Mary’s to work as a lecturer in 1918. However, it would be another 10 years before his world-changing discovery.

On 3rd September 1928, Fleming returned to his lab having spent August on a holiday with his family. Fleming was notorious for his messy lab. Upon returning from a long vacation in 1928, he discovered that he had left out petri dishes of staphylococci, a common bacterium found in 25 percent of healthy people. Upon investigation, he noticed that the bacteria were infected and destroyed by a fungus, which he identified as being from the genus Penicillium. Further investigations revealed that penicillin destroys bacteria by attacking its cell wall and interfering with its ability to reproduce.

Penicillin was able to fight all gram-positive bacteria (a type of bacteria with a more penetrable cell wall), which includes those that cause diphtheria, meningitis, scarlet fever and pneumonia.

Fleming published his discovery in 1929 in the British Journal of Experimental Pathology. However, little attention was paid to his findings at the time. He continued with his experiments but found that cultivation of penicillin was difficult. After having grown the mold, isolating the antibiotic agent proved strenuous. Lacking the funds and manpower needed for more in-depth research, Fleming abandoned his pursuit after a series of inconclusive experiments.

During World War Two, Howard Florey and Ernst Boris Chain from Oxford University managed to get a carefully preserved strain of Fleming’s penicillin. Florey and Chain began large-scale research, hoping to be able to mass-produce the antibiotic.

Mass production began after the bombing of Pearl Harbor, and by D-Day in 1944, enough penicillin had been produced to treat all wounded allied troops.

In 1944, Fleming was knighted by King George VI and became “Sir Alexander Fleming.” The next year Fleming, Florey and Chain jointly won the Nobel Prize for their contribution to developing the antibiotic.

Looking back on the day of his discovery, Fleming once said, “One sometimes finds what one is not looking for. When I woke up… I certainly didn’t plan to revolutionize all medicine by discovering the world’s first antibiotic or bacteria killer. But I suppose that’s exactly what I did.”

Later in life Fleming was decorated with numerous awards: he was an honorary member of almost all medical and scientific societies across the world, he became a “Freeman” of many boroughs and cities, and was awarded honorary doctorate degrees from almost thirty universities across Europe and America. He died aged 73, in 1955.

Fleming’s discovery of penicillin laid the foundation for the development of the antibiotic “wonder drug” that has been credited with saving over 80 million lives. Penicillin revolutionized the medical field and it is likely that most people reading this today have benefited from Fleming’s discovery at some point in their lives. It is for this reason Alexander Fleming deserves to be our sixth Hero of Progress.

Our World in Data | Communicable Disease

A Flu Strain Has Likely Gone Extinct Since 2020

“Flu viruses spread every year and cause seasonal outbreaks. But one type, called influenza B Yamagata, may have completely disappeared…

This likely happened because COVID-19 precautions — such as social distancing, masks, and travel restrictions — sharply reduced social contact. With fewer opportunities to spread from person to person, B Yamagata couldn’t sustain transmission and eventually died out.

Regulatory health agencies like the WHO, European Medicines Agency, and US CDC have recommended removing it from flu vaccines. This could allow room for other strains to be included in seasonal flu vaccines, improving overall vaccine effectiveness.”

From Our World in Data.

UNICEF | Communicable Disease

Pakistan Edges Closer to Eliminating Maternal and Neonatal Tetanus

“Islamabad Capital Territory and Pakistan-Administered Kashmir (PAK) have achieved the elimination of maternal and neonatal tetanus, taking Pakistan closer to interrupting the transmission of this life-threatening disease for mothers and newborns nationwide. The validations were confirmed by the World Health Organization (WHO) following a weeklong final review led by WHO and UNICEF at the request of the Federal Government.

Around 80 per cent of Pakistan’s population (190 million people) now live in areas where the spread of neonatal tetanus remains under controlled limits – less than one case of tetanus per 1,000 live births.”

From UNICEF.

STAT | Communicable Disease

Data Suggest Once-Yearly Shot of Prep Drug Blocks HIV Infection

“Last year, Gilead released data showing that an HIV drug, called lenacapavir, could provide virtually complete protection against infection with just a single injection every six months. The drug, now under regulatory review, was greeted as a breakthrough, the closest thing the field has ever had to a vaccine.

On Tuesday, Gilead published early data suggesting a new formulation of the drug  could be used to prevent infection with just a single shot every year.”

From STAT.

The Guardian | Communicable Disease

New DNA Sequencing System to Fight Superbugs

“Scientists have developed a rapid DNA sequencing system to stem the rise of superbugs by identifying bacterial infections faster and more accurately.

Currently, hospital labs can take as long as seven days to specify bacterial infections, while for some infections a definitive diagnosis may take eight weeks.

In the meantime, doctors may have to give patients broad-spectrum antibiotics, which carry risks of side-effects and complications, may fail and prolong the illness, and can lead to antibiotic resistance and superbugs spreading across wards.

Now scientists have developed a solution. In a UK first, the Medicines and Healthcare products Regulatory Agency (MHRA) and Barts Health NHS trust in London have designed a DNA sequencing programme to diagnose bacterial infections much faster and more accurately.”

From The Guardian.