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01 / 05
Heroes of Progress, Pt. 3: Edward Jenner

Blog Post | Vaccination

Heroes of Progress, Pt. 3: Edward Jenner

Introducing Edward Jenner, the pioneer of the smallpox vaccination - the world's first vaccine.

Today is the third instalment of a new series of articles by HumanProgress.org titled, The Heroes of Progress. This bi-weekly column gives a short overview of unsung heroes, who have made an extraordinary contribution to the wellbeing of humanity. You can find the 2nd part of this series here.

Our third Hero of Progress is Edward Jenner, an 18th century English physician who pioneered the smallpox vaccination – the world’s first vaccine.

Before it was eradicated in 1979, smallpox was one of humanity’s oldest and most devastating scourges. The virus, which can be traced back to pharaonic Egypt, is thought to have killed between 300 and 500 million people in the 20th century alone.

The “speckled monster,” as it was known in 18th century England, smallpox was highly contagious and left the victim’s body covered with abscesses that caused immense scarring. If the viral infection was strong enough, the immune system of the patient collapsed, and the person died.

The mortality rate for smallpox was between 20 and 60 percent, and of those lucky enough to survive, a third were left blind. Among infants, it was 80 percent.

Enter, Edward Jenner.

Born in Gloucestershire in 1749, Jenner was successfully inoculated against smallpox at the age of 8. Between the age of 14 to 21 he apprenticed for a county surgeon in Devon. In 1770, he enrolled as a pupil at St. George’s Hospital in London.

At the hospital Jenner had a variety of interests: he studied geology, conducted experiments on human blood, built and twice launched his own hydrogen balloons, and conducted a particularly lengthy study on the cuckoo bird.

In May 1796, Jenner turned his attention to smallpox. For many years Jenner had heard stories that dairymaids were immune to smallpox because they had already contracted cowpox – a mild disease from cows that resembles smallpox – when they were children.

Jenner found a young dairymaid by the name of Sarah Nelms who had recently been infected with cowpox from Blossom, a cow whose hide still hangs on the wall of St. George’s medical hospital. Jenner extracted pus from one of Nelms’ pustules and inserted it in an 8-year old boy named James Phipps – the son of Jenner’s gardener.

Phipps developed a mild fever, but no infection. Two months later, Jenner inoculated the boy with a fresh smallpox lesion and no disease developed. Jenner concluded that the experiment had been a success and he named the new procedure vaccination from the Latin wordvacca meaning cow.

The American physician Donald Hopkins has noted, “Jenner’s unique contribution was not that he inoculated a few persons with cowpox, but that he then proved that they were immune to smallpox.”

The success of Jenner’s discovery quickly spread around Europe. Napoleon, who was at war with Britain at the time, had all his troops vaccinated, awarded Jenner a medal, and even released two English prisoners at Jenner’s request. Napoleon is cited as having said he could not “refuse anything to one of the greatest benefactors of mankind.”

Jenner made no attempt to enrich himself through his discovery and he even built a small one-room hut in his garden, where he would vaccinate the poor free of charge – he called it the “Temple of Vaccinia.” Later in life he was appointed Physician Extraordinary to King George IV and was made mayor of Berkeley, Gloucestershire. He died on January 26th, 1823, aged 73.

In 1979, the World Health Organization officially declared smallpox an eradicated disease.

The smallpox vaccine laid the foundation for other discoveries in immunology and the amelioration of diseases such as measles (rubeola), influenza (the flu), tuberculosis, diphtheria, tetanus (lockjaw), pertussis (whooping cough), hepatitis A and B, polio, yellow fever and rotavirus.

Jenner’s work has saved untold millions of lives from a disease that has plagued humanity for millennia and it is for that reason that Edward Jenner is our third Hero of Progress.

World Health Organization | Communicable Disease

Burundi Eliminates Trachoma as a Public Health Problem

“The World Health Organization (WHO) has validated Burundi as having eliminated trachoma as a public health problem, making it the eighth country in WHO’s African Region to reach this important milestone…

Trachoma is caused by the bacterium Chlamydia trachomatis and spreads through personal contact, contaminated surfaces and by flies that have been in contact with eye or nose discharge. Repeated infections can lead to scarring, in-turning of the eyelids, and ultimately blindness. Globally, the disease remains endemic in many vulnerable communities where access to clean water and sanitation is limited.”

From World Health Organization.

BBC | Vaccination

World-First Gonorrhoea Vaccine Launched by NHS England

“England will be the first country in the world to start vaccinating people against the sexually transmitted infection gonorrhoea.

It will not be available for everyone. The focus will mainly be on gay and bisexual men with a history of multiple sexual partners or an STI.

The vaccine is 30-40% effective, but NHS England hopes it will reverse soaring numbers of infections.

There were more than 85,000 cases in 2023 – the highest since records began in 1918.”

From BBC.

Vox | Communicable Disease

Scientists Are Dropping Mosquitoes Into Hawaii to Fight Malaria

“For more than a year now, a group of environmental organizations have been dropping biodegradable containers of mosquitoes into honeycreeper habitats on Maui and Kauai from helicopters. Now they’re starting to do it with giant drones. The containers fall to the ground without a top, and when they land the insects escape into the forest.

Critically, these are not your typical mosquitoes. They’re all males, which don’t bite, that have been reared in a lab. More importantly, they contain a strain of bacteria called wolbachia that interferes with reproduction: When those males mate with females in the area, their eggs fail to hatch. (That’s thanks to a bit of biology magic, referred to as the incompatible insect technique, or IIT.) 

The idea is to continually release these special males into honeycreeper habitat where malaria is spreading as a way to erode the population of biting mosquitoes — and thus suppress the spread of disease. The approach has little ecological downside, said Chris Farmer, Hawaii program director at American Bird Conservancy, a conservation group that’s leading the drone effort. Mosquitoes are not native, so local ecosystems and species don’t rely on them.”

From Vox.

ABC News | Communicable Disease

Swiss Medicines Authority Approves Antimalarial Drug for Treatment of Infants

“Switzerland’s medical products authority has granted the first approval for a malaria medicine designed for small infants, touted as an advance against a disease that takes hundreds of thousands of lives — nearly all in Africa — each year.

Swissmedic gave a green light Tuesday for the medicine from Basel-based pharmaceutical company Novartis for treatment of babies with body weights between 2 and 5 kilograms (nearly 4½ to 11 pounds), which could pave the way for hard-hit African nations to follow suit in coming months…

Up to now, antimalarial drugs designed for older children have been administered to small infants in careful ways to avoid overdose or toxicity, in what Bassat called a ‘suboptimal solution’ that the newly designed medicine could help rectify.”

From ABC News.