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Genetically Modified Pigs Could End Organ Transplant Shortage

NPR | Health & Medical Care

Genetically Modified Pigs Could End Organ Transplant Shortage

“Four scientists methodically remove most of the genes from hundreds of pig eggs. They do it by gingerly piercing the egg with a tiny pipette under a microscope to suction out the DNA. Later that day, the scientists inject the edited pig skin cells inside the eggs’ outer membrane. Finally, the scientists zap the combination of cells with two electric shocks to fuse the edited cells with the emptied eggs and then start cell division to create an embryo.

The resulting embryos are surgically implanted into the wombs of adult female pigs. Four months later, cloned piglets are born with 10 genetic modifications designed to make sure their organs don’t grow too big, won’t cause complications like blood clots and won’t be rejected by the human immune system.”

From NPR.

UW–Madison News | Health & Medical Care

Researchers Develop Better Way to Make Painkiller from Trees

“Scientists at the University of Wisconsin–Madison have developed a cost-effective and environmentally sustainable way to make a popular pain reliever and other valuable products from plants instead of petroleum.

Building on a previously patented method for producing paracetamol – the active ingredient in Tylenol – the discovery promises a greener path to one of the world’s most widely used medicines and other chemicals.”

From UW–Madison News.

Wall Street Journal | Noncommunicable Disease

The New, More-Hopeful Face of Alzheimer’s Disease

“For as long as I’ve been practicing medicine, Alzheimer’s disease has been, essentially, a death sentence. You give the diagnosis, and you prepare the patient and the family for the worst.

Until now…

Thanks to new developments in the early detection and management of Alzheimer’s, as well as new medications, many patients can slow the course of the disease and boost their well-being. The result is that more Alzheimer’s patients are able to live relatively normal lives for much longer than previously—several years, at least, and often longer.”

From Wall Street Journal.

NBC News | Vaccination

Chlamydia Vaccine Shows Promise in Early Trial

“An early-stage clinical trial yielded promising results for a chlamydia vaccine, researchers reported Thursday in The Lancet Infectious Diseases. 

There is currently no vaccine to protect against the sexually transmitted infection, which is the most common bacterial STI in the United States…

The phase 1 clinical trial, led by researchers in the United Kingdom and Denmark, found that the experimental vaccine was safe and induced an immune response.”

From NBC News.

The Daily Upside | Vaccination

Moderna Inches Nearer to Successful Cancer Vaccine

“Moderna has long touted that the mRNA vaccine technology it helped revolutionize during the global dash to create a coronavirus vaccine could be repurposed for a variety of medical uses. This vaccine, mRNA-4157, uses the method to train the immune system to identify and attack specific mutations in cancer cells.

The early-stage trial, conducted on patients already prescribed Merck’s Keytruda to treat certain types of head and neck cancer, produced some positive results — and hinted at an even brighter future for the vaccine.”

From The Daily Upside.