“England will be the first country in the world to start vaccinating people against the sexually transmitted infection gonorrhoea.

It will not be available for everyone. The focus will mainly be on gay and bisexual men with a history of multiple sexual partners or an STI.

The vaccine is 30-40% effective, but NHS England hopes it will reverse soaring numbers of infections.

There were more than 85,000 cases in 2023 – the highest since records began in 1918.”

From BBC.

“A psychedelic nasal spray requiring a much shorter period of clinical supervision has shown promise against treatment-resistant depression, giving biotechs hope that this type of drug will become a viable option for healthcare systems to use for mental health conditions. 

Atai Life Sciences and Beckley Psytech announced on Tuesday that patients in their trial of mebufotenin benzoate — based on a compound found in many plants and the venom of the Colorado River toad — demonstrated ‘clinically meaningful’ reductions in depressive symptoms as soon as the day after treatment.

The effect of a single treatment lasted for the trial of eight weeks without plateauing by the end and there were no serious side effects.

The trial of 193 patients in six countries found that the majority were ready for discharge 90 minutes after the dose, a marked improvement from previous trials of psychedelic treatments, where patients required supervision for a whole day.”

From Financial Times.

“For more than a year now, a group of environmental organizations have been dropping biodegradable containers of mosquitoes into honeycreeper habitats on Maui and Kauai from helicopters. Now they’re starting to do it with giant drones. The containers fall to the ground without a top, and when they land the insects escape into the forest.

Critically, these are not your typical mosquitoes. They’re all males, which don’t bite, that have been reared in a lab. More importantly, they contain a strain of bacteria called wolbachia that interferes with reproduction: When those males mate with females in the area, their eggs fail to hatch. (That’s thanks to a bit of biology magic, referred to as the incompatible insect technique, or IIT.) 

The idea is to continually release these special males into honeycreeper habitat where malaria is spreading as a way to erode the population of biting mosquitoes — and thus suppress the spread of disease. The approach has little ecological downside, said Chris Farmer, Hawaii program director at American Bird Conservancy, a conservation group that’s leading the drone effort. Mosquitoes are not native, so local ecosystems and species don’t rely on them.”

From Vox.

“For millions around the world living with type 1 diabetes, treatment to keep blood sugar in check means lifelong daily insulin. However, using insulin comes with its own risks.

If blood sugar drops too low, it can cause hypoglycaemia, or ‘hypos’, which in severe cases may lead to seizures or even death. It is no surprise that constantly balancing between high and low blood sugars takes a heavy toll on both physical and mental health…

Teplizumab offers a completely different approach. Instead of simply replacing insulin, it targets the immune attack that causes type 1 diabetes…

Teplizumab works by retraining the immune system and dialling down the specific cells that target the pancreas. Studies show it can delay the disease and the need for insulin therapy by two to three years, with generally mild side-effects…

The drug is already approved in the US and is under review for routine NHS use, although a few children and teenagers in the UK have also received it through special access programmes.”

From The Conversation.