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01 / 05
Are We Suffering from a Crisis of Meaning?

Blog Post | Health & Medical Care

Are We Suffering from a Crisis of Meaning?

Better material circumstances may not give life meaning, but they can increase human happiness.

For many decades, critics of economic development argued that rising incomes and greater material abundance did not lead to higher levels of happiness. In 1974, Richard Easterlin from the University of Southern California noted that people in richer countries were not happier than people in poor countries. Subsequent research found that the so-called Easterlin Paradox did not exist. Instead, happiness seems to increase with affluence. Today, a different kind of criticism is gaining round. Happiness may be increasing, the critics of economic development concede, but life in a modern capitalist society is more and more devoid of meaning. What are we to make of this criticism?

Writing in New York Magazine, Andrew Sullivan notes, “As we have slowly and surely attained more progress, we have lost something that undergirds all of it: meaning, cohesion, and a different, deeper kind of happiness than the satiation of all our earthly needs. We’ve forgotten the human flourishing that comes from a common idea of virtue, and a concept of virtue that is based on our nature.” Why, he asks, is there “so much profound discontent, depression, drug abuse, despair, addiction, and loneliness in the most advanced liberal societies”? And, he concludes, “For our civilisation, God is dead… We have no common concept of human flourishing apart from materialism, and therefore we stand alone.”

Let us start by unpacking the difference between happiness and meaning. As Steven Pinker observes in his book Enlightenment Now, “We can make choices that leave us unhappy in the short term but fulfilled over the course of a life, such as raising a child, writing a book, or fighting for a worthy cause… People who lead happy but not necessarily meaningful lives have all their needs satisfied: they are healthy, have enough money, and feel good a lot of the time. People who lead meaningful lives may enjoy none of these boons. Happy people live in the present; those with meaningful lives have a narrative about their past and a plan for the future.”

Happiness, then, isn’t everything. But surely it is better to search for the meaning of life on a full, rather than an empty, stomach. And if it happens that the search for meaning requires fasting, let it be undertaken freely rather than as a compulsion. Economic development increases the scope of life choices that are available to individuals. Whether those individuals make use of the increasing number of opportunities to achieve meaningful ends is up to them.

To complicate matters, meaning is different for everyone. Who is to say that the satisfaction I derive from writing an article about the differences between happiness and meaning is truly meaningful? And is my satisfaction as meaningful as the satisfaction of someone who has just completed an extensive stamp collection?

Unlike happiness, which must, by definition, culminate in ecstasy, meaning is infinite and, therefore, impossible to measure. Sullivan, for example, points to the opioid epidemic in America as an example of “profound discontent, depression, drug abuse, despair, addiction, and loneliness.” It is certainly true, as the Princeton University economists Anne Case and Angus Deaton found, that mortality rates among poor whites in the United States have dramatically increased “due to both rises in the number of ‘deaths of despair’ – death by drugs, alcohol and suicide – and to a slowdown in progress against mortality from heart disease and cancer, the two largest killers in middle age.”

But the two authors also found that “midlife mortality rates continue to fall among all education classes in most of the rich world.” Perhaps the opioid crisis among poor whites, who voted in large numbers for Donald J. Trump in the 2016 U.S. presidential election, should have been of greater concern to previous administrations. But do the growing problems experienced by a particular group of Americans mean that the whole of America is suffering from existential angst? And to what extent is despair of poor white Americans representative of the state of the Western world? The data, alas, is devilishly difficult to come by.

The extent to which the West suffers from the crisis of meaning is less than clear. But, even if the problem is a serious one, is democratic capitalism to blame? Did modern-day liberalism kill God and destroy the “common concept of human flourishing apart from materialism”? No one, after all, prevents individuals from finding God on their own or from obtaining a sense of communal belonging by associating with people who have had a similar spiritual experience.

Likewise, complaints about meaningless pursuit of earthly pleasures (materialism) are a recurrent theme in Western writing. Edward Gibbon, to give just one example, refers to “licentiousness” as an important source of the Decline and Fall of the Roman Empire no fewer than 131 times.

Societies, it seems, go through crises of confidence periodically. As my colleague Jason Kuznicki reminded me, the art (Dadaism) and the literature (F. Scott Fitzgerald’s 1925 novel The Great Gatsby) of the 1920s point to a very deep sense of alienation and the loss of meaning that resulted from the carnage of World War I.

A century later, we may well be, as Sullivan writes, in the midst of a similar episode. If so, history suggests that we shall overcome our civilisational angst once more, though, perhaps, we can do so without the false hope of fascism. Lest it be forgotten, in spite of the horrors of the 20th century, humanity has entered the new millennium more numerous, longer-living, richer, healthier, more educated and, even, more peaceful than ever before.

This first appeared in CapX.

Euronews | Health Systems

AI Beats Doctors at Diagnosing Complicated Medical Issues

“For the latest experiment, Microsoft tested an AI diagnostic system against 21 experienced physicians, using real-world case studies from 304 patients that were published in the New England Journal of Medicine, a leading medical journal.

The AI tool correctly diagnosed up to 85.5 per cent of cases – roughly four times more than the group of doctors from the United Kingdom and the United States, who had between five and 20 years of experience.

The model was also cheaper than human doctors, ordering fewer scans and tests to reach the correct diagnosis, the analysis found.”

From Euronews.

Works in Progress | Health & Medical Care

The First Non-Opioid Painkiller

“In the nineteenth century, the invention of anesthesia was considered a gift from God. But post-operative pain relief has continued to rely on opioids, derivatives of opium, the addictive substance employed since ancient times. Although no other drug has managed to match the rapid, potent, and broadly effective relief delivered by opioids, their side effects have led to decades of addiction and overdose, leaving researchers keen to find a better solution.

This all changed in January 2025, when the FDA approved Vertex Pharmaceuticals’s Journavx (suzetrigine): the first non-opioid pain reliever suitable for treating post-surgery pain. Clinical trials found no signs of the problematic side effects associated with opioids: no drug abuse, tolerance, or withdrawal. But this was not an easy win: Vertex and other pharma companies spent decades searching for drugs like this to no avail.”

From Works in Progress.

New Scientist | Health & Demographics

US Heart Attack Deaths Down Almost 90 Percent Since 1970

“Deaths from heart attacks have plummeted in the US over the past 50 years, whereas deaths from chronic heart conditions have skyrocketed, probably due to people living longer.

‘We’ve made some really great progress in certain areas of heart disease mortality, but now we’re seeing this shift,’ says Sara King at Stanford University in California.

She and her colleagues collected data on heart disease deaths from 1970 to 2022 using the US Centers for Disease Control and Prevention’s WONDER database, which tracks all recorded fatalities in the country.

They found that in 2022, heart disease accounted for 24 per cent of all deaths in the US, down from 41 per cent in 1970. The decline is largely thanks to an almost 90 per cent decrease in heart attack deaths, which were once the deadliest form of heart disease…

Even so, heart disease remains the country’s top killer, mainly because deaths from other types of heart disease – mostly chronic conditions – have increased 81 per cent over the same period. For instance, fatalities from heart failure, arrhythmia and hypertensive heart disease have risen 146 per cent, 106 per cent and 450 per cent, respectively.

‘A lot of these conditions are conditions that come with age,’ says King. ‘To us, it seems like people that are now surviving these heart attacks are living longer and having more time to sort of develop these chronic heart conditions.'”

From New Scientist.

The Guardian | Health & Medical Care

Younger Generations Less Likely to Have Dementia, Study Suggests

“Writing in the journal Jama Network Open, researchers in Australia report how they analysed data from 62,437 people aged 70 and over, collected from three long-running surveys covering the US, England and parts of Europe.

The team used an algorithm that took into account participants’ responses to a host of different metrics, from the difficulties they had with everyday activities to their scores on cognitive tests, to determine whether they were likely to have dementia.

They then split the participants into eight different cohorts, representing different generations. Participants were also split into six age groups.

As expected, the researchers found the prevalence of dementia increased by age among all birth cohorts, and in each of the three regions: UK, US and Europe. However, at a given age, people in more recent generations were less likely to have dementia compared with those in earlier generations.

‘For example, in the US, among people aged 81 to 85, 25.1% of those born between 1890–1913 had dementia, compared to 15.5% of those born between 1939–1943,’ said Lenzen, adding similar trends were seen in Europe and England, although less pronounced in the latter.”

From The Guardian.