“Today [6/25/25], we introduce AlphaGenome, a new artificial intelligence (AI) tool that more comprehensively and accurately predicts how single variants or mutations in human DNA sequences impact a wide range of biological processes regulating genes…

Our AlphaGenome model takes a long DNA sequence as input — up to 1 million letters, also known as base-pairs — and predicts thousands of molecular properties characterising its regulatory activity. It can also score the effects of genetic variants or mutations by comparing predictions of mutated sequences with unmutated ones.

Predicted properties include where genes start and where they end in different cell types and tissues, where they get spliced, the amount of RNA being produced, and also which DNA bases are accessible, close to one another, or bound by certain proteins.”

From DeepMind.