“A groundbreaking recent study shows that mosquitoes can be poisoned by the blood of people taking a specific medication. The drug, nitisinone, is already approved by the US Food and Drug Administration for treating certain rare genetic disorders, and researchers have now found that it is also highly effective at killing malaria-carrying mosquitoes.

The concept of poisoning mosquitoes through their blood meals isn’t entirely new. In the past, scientists have investigated ivermectin, a widely used antiparasitic drug, as a potential mosquito-killing agent. The idea is simple: When a mosquito bites a person or animal treated with ivermectin, the drug enters the mosquito’s system and ultimately kills it. However, ivermectin has limitations—it works relatively slowly, taking up to four days to kill mosquitoes, and its effects wear off quickly in the bloodstream.

Nitisinone presents a more promising alternative. Unlike traditional insecticides, which typically target the mosquito’s nervous system, nitisinone disrupts a crucial enzyme (HPPD) that mosquitoes need to digest their blood meal. Without this enzyme, mosquitoes experience a metabolic shutdown, leading to death within 24 hours—far faster than with ivermectin.

Perhaps most excitingly, nitisinone appears to be effective at much lower doses than previously expected. Even blood from people taking small amounts of the drug proved lethal to mosquitoes. This means that individuals in malaria-endemic regions could potentially take a safe low dose of nitisinone, turning their blood into a mosquito-killing agent without significant side effects.”

From Quillette.