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01 / 05
Scientists Just Made CRISPR Three Times More Effective

ScienceDaily | Health & Medical Care

Scientists Just Made CRISPR Three Times More Effective

“Northwestern University chemists have unveiled a new type of nanostructure that dramatically improves CRISPR delivery and potentially extends its scope of utility.

Called lipid nanoparticle spherical nucleic acids (LNP-SNAs), these tiny structures carry the full set of CRISPR editing tools — Cas9 enzymes, guide RNA and a DNA repair template — wrapped in a dense, protective shell of DNA. Not only does this DNA coating shield its cargo, but it also dictates which organs and tissues the LNP-SNAs travel to and makes it easier for them to enter cells.

In lab tests across various human and animal cell types, the LNP-SNAs entered cells up to three times more effectively than the standard lipid particle delivery systems used for COVID-19 vaccines, caused far less toxicity and boosted gene-editing efficiency threefold. The new nanostructures also improved the success rate of precise DNA repairs by more than 60% compared to current methods.”

From ScienceDaily.

Scientific American | Scientific Research

Astronomers Discover Primordial Extreme Objects in the Universe

“At the heart of many galaxies lie supermassive blackholes. These engines power quasars—active galactic nuclei that emit some of the brightest light astronomers can possibly see in the sky. How these extreme objects formed in the earliest years of the universe—when the cosmos was less than a billion years old—has long been something of a mystery.

But now, the European Space Agency's Euclid Space Telescope has identified a clutch of primordial quasars, dating to some 13 billion years ago—putting them among the oldest of these objects ever found in the universe.

Ancient quasars offer glimpses into the universe in its chaotic infancy; but actually finding these primordial objects can be very difficult. Because they formed so long ago, they are extremely far away from Earth, which can cause their bright light to be mistaken for a signal of a more run-of-the-mill celestial object.”

From Scientific American.

Smithsonian Magazine | Scientific Research

Ancient DNA Recovered That Humans Left Behind in Caves

“Scientists have long been fascinated by prehistoric cave art, which offers a rare glimpse into the creative minds of our ancestors. Now, they might finally be able to ‘meet’ some of the artists who created these masterpieces thousands of years ago.

Traces of ancient DNA from humans can survive for millennia on cave walls and in rock art, scientists report in a new paper published in June in the journal Nature Communications.

In the past, scientists have extracted ancient DNA from cave dirt, chewing ‘gum’ and a 20,000-year-old pendant. But no one had recovered it from rock art, until now.

‘It’s the start of a new era,’ study co-author Genevieve von Petzinger, a paleoanthropologist at the University of the Witwatersrand, tells NewScientist’s Alison George. ‘This gives us the potential to meet the actual artists, the individuals who did this art. It’s extraordinary.'”

From Smithsonian Magazine.

New York Times | Scientific Research

This Cell Feeds, Grows and Reproduces. And It’s Manmade.

“Scientists have long dreamed of discovering the alchemy by which chemicals can be turned into life. On Wednesday, a team at the University of Minnesota announced that it had taken a major step toward that vision.

Blending together dozens of ingredients, the researchers have synthesized simple cells that feed, grow, reproduce and compete with one another for food. If these cells are not yet fully alive, they have most of the hallmarks of life.”

From New York Times.

Vesuvius Challenge | Scientific Research

Herculaneum Scroll Read Without Ever Being Physically Opened

“For almost 2,000 years, the carbonized library of Herculaneum has kept a cruel bargain: its scrolls survived the eruption of Mount Vesuvius, but only by becoming too fragile to open. To read one was to destroy it. Hundreds of rolls have therefore remained sealed, their contents preserved yet unreachable.

Today that changes. We have completely virtually unwrapped and read PHerc. 1667 — the scroll the Vesuvius Challenge community knows as Scroll 4 — without ever touching its pages. It is the first Herculaneum papyrus to be digitally unrolled and read in full, end to end, and made available for sustained scholarly study.”

From Vesuvius Challenge.