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01 / 05
Mitochondria Transplants Could Lengthen Lives

The Economist | Life Expectancy

Mitochondria Transplants Could Lengthen Lives

“Mitochondria, the organelles in question, are best known as power packs—places where glucose molecules are disassembled to release the energy that drives metabolism… Mitochondria also initiate the suicide of cells that are damaged, cancerous or surplus to requirements; act as communications centres for signalling proteins; and regulate levels of calcium ions—which are involved in signalling as well…

With such a wide range of vital tasks to perform, it is hardly surprising that faulty mitochondria cause or contribute to many diseases. Some of these are congenital, the result of faulty mitochondrial genes. And some, such as diabetes and cardiovascular problems, occur when mitochondria wear out in old age. If a technique to transplant healthy ones could be made to work, its potential would be enormous.

One person trying to make this happen is James McCully of Harvard Medical School. He has developed a treatment for premature babies who, because the mitochondria in their heart muscles have been damaged by ischemia (the medical term for restricted blood flow), need the assistance of a heart-lung machine. Without such intervention, they would die. Even with it, only 60% survive.

In a trial, the results of which were published just over four years ago, Dr McCully improved that rate to 80%. His technique involves taking a small piece of tissue from the child’s abdominal wall, breaking it up to liberate the mitochondria, separating them from other cellular gubbins in a centrifuge and perfusing them back into the failing heart.

There is a chance that Dr McCully’s results may have been a statistical fluke—only ten babies were given the procedure in his experiments—but it suggests his technique is at least safe. He and his colleagues found that their procedure immediately increased production of signalling molecules in the babies, which stopped inflammation and cellular suicide. And, shortly afterwards, the perfused mitochondria took up residence in the damaged heart muscle, restoring its function in the longer term.

Dr McCully now hopes to extend this approach, which is currently being assessed by America’s Food and Drug Administration, to other ischemia-affected tissues, including adult hearts, lungs, kidneys and limbs. He is not alone. Lance Becker of the Feinstein Institute in New York plans to test a similar technique on premature babies. And Melanie Walker of the University of Washington, in Seattle, has just published the results of an experiment on a different type of ischemia—that which causes strokes.”

From The Economist.

Wall Street Journal | Life Expectancy

Drop in Drug Overdoses Boosts US Life Expectancy to All-Time High

“Life expectancy in the U.S. reached a record high in 2024 following a substantial decline of drug-overdose deaths, according to figures released by the federal government Thursday.

The life expectancy at birth for the average American was 79 years old in 2024, up 0.6 year from the year prior, according to a report from the Centers for Disease Control and Prevention’s National Center for Health Statistics. The increase signals a rebound from declines in life expectancy during the coronavirus pandemic and progress in combating the opioid crisis.

The agency reported that deaths related to drug overdose decreased by more than 26% between 2023 and 2024, marking the largest year-to-year drop in those types of fatalities recorded by the federal government.”

From Wall Street Journal.

University of Chicago | Pollution

China Has Reduced Pollution, Improved Life Expectancy

“Particulate pollution in China declined by 41 percent between 2013 and 2022 and by 3.4  percent from 2021 to 2022 alone. Because of these air quality improvements, the average Chinese citizen can expect to live 2 years longer, provided the reductions are sustained. Beijing province experienced the largest decline in pollution, dropping 54.1 percent in just nine years. If this success is sustained, the average person living there could expect to live 3.9 years longer.”

From University of Chicago.

Blog Post | Environment & Pollution

Climate Litigation Can’t Fix the Past, but It Can Hinder the Future

Dealing with climate change requires technological innovation and economic growth, not legal warfare between nations.

Summary: The International Court of Justice has suggested nations could be held liable for historic greenhouse gas emissions, opening the door to lawsuits over centuries of industrial activity. Yet this approach risks punishing the very innovations that lifted billions out of poverty and advanced human health and flourishing. Lasting progress on climate challenges will come not from courtroom battles, but from technological solutions and continued economic development.


The International Court of Justice’s advisory opinion purporting to establish legal grounds that would allow nations to sue one another over climate damages represents judicial overreach that ignores economic history and threatens global development. While the opinion was undeniably legally adventurous, the framework it envisages would be practically unworkable as well as economically destructive.

The ICJ’s ruling suggests countries can be held liable for historical emissions of planet-warming gases. That creates an accounting nightmare that no legal system can resolve. How does one calculate damages from coal burned in Manchester in 1825 versus emissions from a Beijing power plant in 2025? How does one stack up the harm caused by a warming world against the benefits of industrialization?

Britain began large-scale coal combustion during the Industrial Revolution, when atmospheric CO2 concentrations were 280 parts per million and climate science did not exist. Holding Britain liable for actions taken without knowledge of consequences violates basic principles of jurisprudence. The same applies to the United States, whose early industrialization occurred during an era when maximizing economic output was considered unambiguously beneficial to human welfare.

Critics of historical emissions ignore what those emissions purchased. British coal combustion powered textile mills that clothed much of the world, steam engines that revolutionized transportation, and factories that mass-produced goods previously available only to elites. American industrialization followed, creating assembly lines, electrical grids, and chemical processes that form the backbone of modern civilization.

These developments were not zero-sum exercises in resource extraction. They created knowledge, infrastructure, and institutions that benefited everyone. The steam engine led to internal combustion engines, which enabled mechanized agriculture that now feeds 8 billion people. Coal-powered steel production made possible skyscrapers, bridges, and the infrastructure that supports modern cities, where most humans now live longer, healthier lives than their ancestors.

The data on human welfare improvements since industrialization began are explicit. Global life expectancy increased from approximately 29 years in 1800 to 73 years today. Infant mortality rates fell from over 40 percent to under 3 percent. Extreme poverty, defined as living on less than $2.15 per day in purchasing power parity terms, declined from over 80 percent of the global population in 1800 to under 10 percent today.

Nutrition improved dramatically. Caloric availability per person has increased by roughly 40 percent since 1960 alone, while food prices relative to wages fell consistently. Height, a reliable indicator of childhood nutrition, increased significantly across all regions. Educational attainment expanded from literacy rates below 10 percent globally in 1800 to over 85 percent today.

These improvements correlate directly with energy consumption and industrial development. Countries that industrialized earliest experienced these welfare gains first, then transmitted the knowledge and technology globally. The antibiotics developed in American and European laboratories now save lives worldwide. The agricultural techniques pioneered in industrialized nations now feed populations that would otherwise face starvation.

The International Court of Justice’s liability framework threatens to undermine the very mechanisms that created these welfare improvements. Innovation requires investment, which requires confidence in property rights and legal stability. If successful economic development subjects countries to retroactive liability, the incentive structure tilts away from growth and toward stagnation.

Consider current developing nations. Under this legal framework, should India or Nigeria limit their industrial development to avoid future liability? Should they forgo the coal and natural gas that powered Western development? That creates a perverse situation where the legal system penalizes the exact processes that lifted billions from poverty.

The framework also ignores technological solutions. The same innovative capacity that created the Industrial Revolution is now producing renewable energy technologies, carbon capture systems, and efficiency improvements that address climate concerns without sacrificing development. Market incentives and technological progress offer more promise than legal blame assignment.

Which emissions count as legally actionable? All anthropogenic CO2 remains in the atmosphere for centuries, making every emission since 1750 potentially relevant. Should liability begin with James Watt’s steam engine improvements in 1769? With the first coal-fired power plant? With Henry Ford’s assembly line? The temporal boundaries are arbitrary and politically motivated rather than scientifically determined.

Similarly, which countries qualify as defendants? The largest current emitters include China and India, whose recent emissions dwarf historical American and British totals. China alone now produces more CO2 annually than the United States and Europe combined. Any coherent liability framework must address current emissions, not just historical ones.

And where would the money go? This aspect of the case was brought up by Vanuatu. If the island nation receives compensation from the UK and the US, should it not be obliged to pay the British and the Americans for a plethora of life-enhancing Western discoveries, including electricity, vaccines, the telephone, radio, aviation, internet, refrigeration, and navigation systems?

Climate adaptation and mitigation require technological innovation and economic growth, not legal warfare between nations. The countries that industrialized first possess the technological capacity and institutional knowledge to develop solutions to today’s problems. Channeling resources toward litigation rather than innovation represents a misallocation that benefits lawyers while harming global welfare.

The ICJ opinion reflects wishful thinking rather than practical policy. Legal frameworks cannot repeal economic reality or reverse the historical processes that created modern prosperity. Instead of seeking retroactive justice for emissions that enabled human flourishing, policymakers should focus on technologies and institutions that sustain development while addressing environmental concerns. The alternative is a world where legal systems punish success and innovation while offering nothing constructive in return.

The original version of this article was published in National Review on 8/12/2025.