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01 / 05
Drug Firms Are Building Their Own Version of AlphaFold

Nature | Scientific Research

Drug Firms Are Building Their Own Version of AlphaFold

“AlphaFold, the revolutionary, Nobel prize-winning tool for predicting protein structures, has a problem: it’s running low on data.

The latest version of the artificial intelligence (AI) model, AlphaFold 3, has been touted as a game-changer for drug discovery, because it can model the interaction of proteins with other molecules, including drugs.

But a lack of examples of these interactions in the data underpinning AlphaFold — hundreds of thousands of publicly available protein structures — is holding the tool back for the applications that drug companies are most interested in, say scientists.

A consortium of leading pharmaceutical companies announced plans today to make their own AlphaFold-3-inspired AI model using thousands of protein structures that are currently secreted away in company vaults. This is in addition to the more than 200,000 protein structures freely available in the Protein Data Bank (PDB).

‘The data that’s missing from the PDB is exactly the data that’s present in our internal data,’ says John Karanicolas, head of computational drug discovery at the pharma company AbbVie in Chicago, Illinois, and part of the effort, called the AI Structural Biology Consortium.

The consortium’s model will be based on OpenFold 3, a fully open-source reproduction of AlphaFold 3 that has been developed by academic researchers (using only publicly available data) and is due to be released in April. But there are no plans to make the consortium’s model available beyond member companies, which include AbbVie, Johnson & Johnson, Sanofi and Boehringer Ingelheim.”

From Nature.

Ars Technica | Scientific Research

These 60,000-Year-Old Poison Arrows Are Oldest Yet Found

“Archaeologists have now found traces of a plant-based poison on several 60,000-year-old quartz Stone Age arrowheads found in South Africa, according to a new paper published in the journal Science Advances. That would make this the oldest direct evidence of using poisons on projectiles—a cognitively complex hunting strategy—and pushes the timeline for using poison arrows back into the Pleistocene.”

From Ars Technica.

New York Times | Scientific Research

430,000-Year-Old Wooden Tools Are the Oldest Ever Found

“Early hominins in Europe were creating tools from raw materials hundreds of thousands of years before Homo sapiens arrived there, two new studies indicate, pushing back the established time for such activity. The evidence includes a 500,000-year-old hammer made of elephant or mammoth bone, excavated in southern England, and 430,000-year-old wooden tools found in southern Greece — the earliest wooden tools on record.

The findings suggest that early humans possessed sophisticated technological skills, the researchers said. Katerina Harvati, a paleoanthropologist at the University of Tübingen in Germany and a lead author of the wooden-tool paper, which was published on Monday in the journal PNAS, said the discoveries provided insight into the prehistoric origins of human intelligence.

Silvia Bello, a paleoanthropologist at London’s Natural History Museum and an author on the elephant-bone study, which was published last week in Science Advances, concurred.

The artifacts in both studies, recovered from coal-mine sites, were probably produced by early Neanderthals or a preceding species, Homo heidelbergensis. Homo sapiens emerged in Africa more than 300,000 years ago, and the oldest evidence of them in Europe is a 210,000-year-old fossil unearthed in Greece. By the time Homo sapiens established themselves in Britain 40,000 years ago, other hominins had already lived there for nearly a million years.”

From New York Times.

IEEE Spectrum | Space

The Quest to Build a Telescope to Hear the Cosmic Dark Ages

“The instrument is called LuSEE-Night, short for Lunar Surface Electromagnetics Experiment–Night. It will be launched from Florida aboard a SpaceX rocket and carried to the moon’s far side atop a squat four-legged robotic spacecraft called Blue Ghost Mission 2, built and operated by Firefly Aerospace of Cedar Park, Texas…

A moon-based radio telescope could help unravel some of the greatest mysteries in space science. Dark matter, dark energy, neutron stars, and gravitational waves could all come into better focus if observed from the moon. One of Burns’s collaborators on LuSEE-Night, astronomer Gregg Hallinan of Caltech, would like such a telescope to further his research on electromagnetic activity around exoplanets, a possible measure of whether these distant worlds are habitable. Burns himself is especially interested in the cosmic dark ages, an epoch that began more than 13 billion years ago, just 380,000 years after the big bang. The young universe had cooled enough for neutral hydrogen atoms to form, which trapped the light of stars and galaxies. The dark ages lasted between 200 million and 400 million years.”

From IEEE Spectrum.

BBC | Scientific Research

Landscape Beneath Antarctica’s Icy Surface Revealed in Detail

“A new map has unmasked the landscape beneath Antarctica’s ice in unprecedented detail, something scientists say could greatly enhance our understanding of the frozen white continent.

Researchers used satellite data and the physics of how Antarctica’s glaciers move to work out what the continent might look like beneath the ice.

They found evidence of thousands of previously undiscovered hills and ridges, and say their maps of some of Antarctica’s hidden mountain ranges are clearer than ever before.

While the maps are subject to uncertainties, the researchers believe the new details could shed light on how Antarctica will respond to climate change – and what that means for sea-level rise.”

From BBC.