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01 / 05
A New Vaccine May Fix Africa’s “Meningitis Belt”

Telegraph | Vaccination

A New Vaccine May Fix Africa’s “Meningitis Belt”

“For at least a century outbreaks of meningitis have swept across a swathe of Africa running from Senegal to Ethiopia, killing tens of thousands of people every few years.

Desert winds, dust storms, and fragile health systems mean the bacteria that cause the disease can infect people more easily, causing regular epidemics in what’s known as the meningitis belt.

If not treated, this type of bacterial meningitis can kill within hours. One in six who catch it will die and many survivors suffer complications like hearing loss, brain damage and amputations.

Scientists have been battling to break the cycle for decades, but have had only limited success – largely because meningococcal disease is not just caused by one type of bacterium, but many.

But they may now have a new weapon in their arsenal. Along the belt, countries have begun rolling out a five-in-one vaccine that targets the varieties of Neisseria meningitidis bacteria that are responsible for almost all epidemic meningitis in sub-Saharan Africa.

It is the first major breakthrough since the MenAfriVac vaccination was introduced in 2010, which proved highly effective against serogroup A, effectively eliminating the leading cause of meningitis and saving millions of lives.

The new jab, called Men5CV, protects against four more serogroups – C, Y, W and X – and experts are hailing it as the next milestone towards the World Health Organization’s (WHO) goal of eliminating epidemic meningitis by 2030.

The vaccine is already being rolled out in Niger and Nigeria, while Mali, Ghana, Burkina Faso, Chad and Togo all have plans to introduce it in the coming months.”

From Telegraph.

The Lancet | Vaccination

New Studies Show Robust Malaria Vaccine Effectiveness

“TS,S/AS01E was first introduced within the Malaria Vaccine Implementation Programme in selected areas in Ghana, Kenya, and Malawi. A series of post-introduction observational studies were initiated in these areas to assess RTS,S/AS01E safety and effectiveness in real-world settings. Here, we report the results of the interim analysis of the EPI-MAL-003 study secondary objectives related to vaccine effectiveness…

Over 12 months after the third RTS,S/AS01E dose, country-adjusted IRRs suggest a 30% reduction in any malaria and a 58% reduction in severe malaria. No cerebral malaria occurred in the vaccinated children over the follow-up period”

From The Lancet.

Wall Street Journal | Vaccination

Moderna, Merck Report Positive Cancer-Vaccine Study Results

“Moderna and Merck’s cancer vaccine reduced the risk of relapse or death for melanoma patients, five-year data from a Phase 2b trial showed.

The companies on Tuesday said the vaccine, in combination with Merck’s immunotherapy Keytruda, reduced the risk of recurrence or death by 49% compared with Keytruda alone.

‘We continue to invest in our platform in oncology because of encouraging outcomes like these, which illustrate mRNA’s potential in cancer care,’ said Kyle Holen, a senior vice president at Moderna.

The companies had previously released promising three-year data from the study, and on Tuesday they said the treatment ‘continued to demonstrate sustained and clinically meaningful improvement’ in reducing the risk of death and relapse.

The companies currently have eight Phase 2 and Phase 3 clinical trials across multiple tumor types, including melanoma, non-small-cell lung cancer, bladder cancer and renal cell carcinoma.”

From Wall Street Journal.

New York Times | Vaccination

Vaccines Are Helping Older People More than We Knew

“In 21 studies involving more than 104 million participants in Europe, Asia and North America, vaccination against shingles was associated with a 24 percent reduction in the risk of developing dementia. Flu vaccination was linked to a 13 percent reduction. Those vaccinated for pneumococcal infection had a 36 percent reduction in Alzheimer’s risk.

The Tdap vaccine against tetanus, diphtheria and pertussis (whooping cough) is recommended for adults every 10 years, with vaccination among older adults often prompted by the birth of a grandchild, who cannot be fully vaccinated for months. It was associated with a one-third decline in dementia.

Other researchers are investigating the effects of shingles vaccination on heart attacks and stroke and of Covid vaccination on cancer survival.

What causes such vaccine bonuses? Most hypotheses focus on the inflammation that arises when the immune system mobilizes to fight off an infection.”

From New York Times.

Telegraph | Vaccination

Major Milestone in Development of Nipah Virus Vaccine

“An Oxford-designed vaccine for Nipah virus has launched phase two trials, in a ‘major milestone’ for efforts to curb the deadly pathogen and boost pandemic preparedness.

The disease – which inspired the Hollywood blockbuster Contagion – is rare but extremely deadly, with a fatality rate as high as 75 per cent. The World Health Organization considers it a priority pathogen for research, as no vaccines or treatments currently exist to tackle it.

This month a jab developed by the University of Oxford, which uses the same ChAdOx platform as the institution’s Covid-19 shot, became the first Nipah vaccine candidate to enter phase two clinical trials to assess safety and the immune response.

It is also the first vaccine to be trialled in a region directly affected by the virus. Bangladesh has sporadic outbreaks every year, with Nipah mostly spreading from fruit bats to people via contaminated raw date palm sap – although some human-to-human transmission through bodily fluids is also possible.”

From Telegraph.